Effect of Vipera ammodytes ammodytes Snake Venom on the Human Cytokine Network
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چکیده
منابع مشابه
Purification and properties of a kininogenin from the venom of Vipera ammodytes ammodytes.
A kininogenin (EC 3.4.21.8) was purified from the venom of Vipera ammodytes ammodytes (European sand viper) by a combination of gel filtration and ion-exchange chromatography. The enzyme is approximately six times more active than bovine trypsin in its ability to release vasoactive peptides from a plasma precursor. The kininogenin is a glycoprotein containing 18-20% by weight of carbohydrate. I...
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This study illustrates the main morphological structures of the cloaca of six adult horned vipers Vipera ammodytes (3.3). The coprodeum is characterized by smooth and thin mucosa, with moderate vasculature. In the centre of the coprodeum the anal sphincter is located, which separates the coprodeum from the colon. Structures of the urodeum are divided by two highly developed septa in female vipe...
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Envenoming bites by Vipera ammodytes ammodytes (the long-nosed viper) can cause life-threatening neurotoxicity, particularly in children. We investigated the mechanisms of the neurotoxicity of ammodytoxin A, the principal toxin in the venom of these snakes, in isolated nerve-muscle preparations from mice. The toxin was bound selectively to the neuromuscular junction, and at concentrations simil...
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The Nose-horned Viper (Vipera ammodytes) is one of the most widespread and venomous snakes in Europe, which causes high frequent snakebite accidents. The first comprehensive venom characterization of the regional endemic Transcaucasian Nose-horned Viper (Vipera ammodytes transcaucasiana) and the Transdanubian Sand Viper (Vipera ammodytes montandoni) is reported employing a combination of intact...
متن کاملEnzymatic activity and inhibition of the neurotoxic complex vipoxin from the venom of Vipera ammodytes meridionalis.
Vipoxin from the venom of Vipera ammodytes meridionalis is an unique neurotoxic complex between a toxic phospholipase A2 and a highly homologous non-toxic protein inhibitor. It is an example of evolution of a catalytic and toxic function into inhibitory and non-toxic one. The activity of the V. ammodytes meridionalis toxin is 1.7 times higher than that of the closely related (92% sequence ident...
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ژورنال
عنوان ژورنال: Toxins
سال: 2018
ISSN: 2072-6651
DOI: 10.3390/toxins10070259